Monday June 18, 2012, 9:00 am - 5:00 pm, Santa Clara, California
This workshop will present a critical evaluation of the use of microfluidics in bioanalytics, medical diagnostics and food science. Besides the standard bioanalytical devices, and thanks to fundamental advances in micro and nanofluidics, many applications have integrated nanotechnology elements: we will particularly discuss food and feed applications; for instance, the use of nanoporous membrane developed to filter off bacteria and viruses in drinking water will be presented in the workshop.
This course will review the basis of microfabrication and microfluidics which is a fundamental knowledge to understand their application in bioanalytics as well as their use in drinking water nanofiltration for instance.
The recent evolution of research in miniaturisation has given building blocks such as microarrays and rapid separation devices to the scientific community. The future opportunity in the miniaturisation of analytical tools in proteomics relies on the integration of an increased number of functions (sample extraction, pre-concentration, etc) in order to avoid any external fluid handling and/or sample transfer along the entire analysis workflow.
The rationalisation of proteomic tools presents a fantastic opportunity for the development of microfluidics. Several sequential and cumbersome steps can indeed be simplified by using modular approaches for sample preparation. This trend is exemplified by the recent introduction by Agilent Technologies of lab-on-a-chip multidimensional chromatography coupled to mass spectrometry. Current and future developments in the field of nanospray sampling will also be reviewed and criticised during the workshop.
The use of new tools in the feed and food market has also grown in the recent time. For instance, the use of nanoporous material used to filtrate water has enabled to reduce massively the use of chlore in the disinfection of drinking water network in many cities. This advanced coupled to nanoactive carbon black is expected to treat drinking water which has been contaminated with drugs or pesticides for instance.
On the other hand, the integration of specific nanoparticles in polymer enables to reduce the permeation of gas into plastic bottles, which permit the prolongation of food conservation. The use of these technologies is of prime interest in the different domain of application but it can also bring some fear or irrational understanding from the consumer. Some critical consideration of the use of micro and nanotechnology in relation with food chemistry will be discussed.
The objective of the course is dual; first it should help the scientific community to better know the state of the art and limitation of nano/microfabrication and on the other hand, understand how the related technology have recently been implemented in different domain of application such as medical diagnostics and food chemistry. Review of actual application will be presented and should bring a clear view of the potential and limitation of micro- and nano-fluidics in the different field of applications.
The course targets different sets of attendees:
For each participant, the course will give a clear overview of the current use of microfluidics in modern life sciences as well as its growth opportunity in the future.
Joël S. Rossier studied physical chemistry at the Swiss Federal Institute of Technology in Zurich - ETHZ, followed by a Ph.D. thesis at the Laboratory of Analytical and Physical Electrochemistry in Lausanne, under the supervision of Prof Hubert Girault. His work partly done in collaboration with Kansas University was focused on the development of µ-chips for diagnostics and electrophoresis applications and was rewarded by the BioRad's Young Scientist Electrophoresis Research Award in 1998.In 1999, Joël S. Rossier co-founded DiagnoSwiss, a Swiss based company developing microfluidic diagnostics and proteomics systems in collaboration with multinational companies such as Biomérieux and Agilent Technologies which launched in 2006 a product (OFFGELTM-electrophoresis) based on DiagnoSwiss’ technology portfolio.In 2010, he joined the direction the food control authority of the canton Valais (Switzerland) where he leads chemical and biological laboratory for food safety.
Joël S. Rossier is author of more than 45 peer-reviewed research articles and 14 patent applications. He is regularly invited as reviewer and editor for international scientific journals (Editorial Board of Electrophoresis, NanoMedicine and Expert Opinion in Medical Diagnostics), and he co-edited a book entitled Microfluidic Application in Biology (Wiley publisher 2006). Dr Rossier co-founded the Swiss Proteomics Society and, in order to keep a strong link to academic institutions, he has been appointed in 2005 as external lecturer at the Swiss Federal Institute of Technology in Lausanne (EPFL).