F. Chen, G. Wang, S. Inturi, D.S. Backos, L.P. Wu, S. Moein Moghimi, D. Simberg
University of Colorado,
Keywords: drug delivery, immune recognition
Summary:Complement is the system of 30+ serum proteins that represents the first immune barrier to invading pathogens1. Activation of complement cascade results in coating (opsonization) of nanoparticles with complement component C3 and release of extremely potent proinflammatory factors C3a and C5a. We will cover the mechanisms of complement activation and immune recognition on the surface of biopolymer coated iron oxide nanoparticles in mice and humans as function of surface properties, coating chemistry and adsorption of protein corona. We will discuss some of the synthetic strategies and challenges to block complement activation in mice and human subjects. Understanding the mechanisms of immune recognition and complement activation can trigger rational design of improved imaging and drug delivery systems. 1. Ricklin, D.; Hajishengallis, G.; Yang, K.; Lambris, J. D., Complement: A Key System for Immune Surveillance and Homeostasis. Nat Immunol 2010, 11, 785-797.