A. Sharma, F. Soetaert, S.K. Kandala, C.L. Dennis, R. Ivkov
Johns Hopkins University School of Medicine,
Keywords: hyperthermia, nanoparticle, iron oxide, magnetostructural, specific loss power, cancer
Summary:We provide a detailed characterization of the heating performance of various single-crystallite and multi-crystallite iron oxide nanoparticles as agents for thermal dose delivery in hyperthermic treatment of tumors. We provide optimal nanoparticle design criteria and alternating magnetic field (AMF) driving conditions for therapeutically relevant thermal doses in tumors. The specific loss powers (SLP) of various commercial and proprietary iron oxide nanoparticles were experimentally evaluated as a function of externally applied magnetic field (AMF) magnitudes and frequencies. The measured SLP values were correlated with magnetostructural properties using SQUID magnetometry, electron microscopy, and X-ray diffractometry. The magnetic, structural, and heating data will be presented in the context of prevailing models and with a view to applications for cancer hyperthermia in mouse models.