TECHNOLOGY SUMMARY

The AMProtection patent-pending coating is comprised of the covalent attachment of antimicrobial peptide (AMP) Chrysophsin-1 onto a surface using a linker molecule. These AMPs utilize unique mechanisms against bacteria, making them broadly antimicrobial with a low likelihood of resistance. Catheter-associated urinary tract infections (CAUTIs) cause 12-25% morbidity in patients and start at $1,000 per case; thus, the best course is to prevent their occurrence. Preventative competing methods include catheters dip-coated with silver, traditional antibiotics or chemical antiseptics. However, several recent studies had called the effectiveness of silver into question, whereas desorption of antibiotic- and antiseptic-coatings causes a higher chance of antibiotic resistance and toxic side effects. The AMProtection innovation is differentiated because it is broad-spectrum, surface-tethered (therefore will not release from the surface), biocompatible, and does not promote resistance. The potential impact on the urinary catheter market, which is $1 billion in the U.S., half of which are antimicrobial coated catheters, depends on the licensee (for example, BARD owns 85% of the market share). However, we expect that per 10,000 coated catheters sold, we reduce 80% of CAUTIs, 200 patient hospital days, and tens of millions of dollars in unreimbursed never event expenses.

AREA/MATURITY/AWARDS

Primary Application Area: Biotech, Pharma, Medical Devices

Technology Development Status: Prototype

Technology Readiness Level: TRL 3

Vetted Programs/Awards: • Venture Well E-Team Stages 1-3 Awardee (2015-2017)
• The VentureForum 5-Minute Pitch Competition Awardee (2015-2017)
• MATTO New Venture Showcase Pitch (2017)
• Hitchcock Innovation Prize Winner (2016)
• TechSandBox Pitchfest Winner (2016)
• M2D2 100k Challenge Poster Presenter (2016-2017)
• NCET2 “Top 40 University Startups 2017” (2017)

SHOWCASE SUMMARY

Organization Type: Early-mid-stage Startup

Showcase Booth #: 22M

Website: http://amprotection.us

GOVT/EXTERNAL FUNDING SOURCES

External Funding to Date: • VentureWell E-Team Stages 1-3 ($25000)
• The VentureForum 5-Minute Pitch Competition ($3000)
• Hitchcock Innovation Prize ($20000)
• Individual Angel Investment ($25000)