A Method of Making Biocompatible Antioxidant Ceria Nanoparticles Loaded in Multi-layer Polymer Films on Electrode

Y. Hu
Brown University,
United States

Keywords: Biocompatible, antioxidant, CeO2


Reactive oxygen species (ROS) generate in vivo are generally related to cancer and severe immune reactions. Several kinds of antioxidant nanoparticles are developed by chemists and biologists to reduce the ROS level in vivo.1 Cerium oxide (ceria) nanoparticles exhibit recyclable antioxidant property due to facile electron transfer between Cerium (III) and Cerium (IV). Recent studies reveal that ceria nanoparticles at the size of 5 nm are efficient and non-toxic for quenching ROS in vivo.1,2 Here, we developed a highly reproducible method to generate stable and biocompatible ceria nanoparticles which can be used in vivo to control the ROS level induced by immune reactions.