S.M. Moghimi, Z.S. Farhangrazi
Keywords: peptidic, nanosystem, brain, bbb
Summary:We provide a simple strategy for self-assembly of a peptidic nanosystem capable of rapidly crossing the blood-brain barrier (BBB) on intravenous injection and without disruption of the BBB. The engineered nanosystem targets two receptors on cerebral endothelial cells and delivers nucleic acid medicines to the brain. Transcytosed nanoparticles interact with microglial cells and neurons and deliver their cargo to these cells. We further provide pharmacological proof of concept through unprecedented silencing in the brain with functional siRNA molecules delivered with this nanosystem.