TECHNOLOGY SUMMARY

New antibiotic drug candidates were discovered based on our biological research of bacterial transcription system. These first-in-class antimicrobial small molecules with new mechanism of action displayed excellent bactericidal effects against bacteria including antibiotic-resistant pathogens, unlike any current antibiotics on the market. These molecules target the important bacterial protein-protein interactions not existing in mammals, therefore demonstrated no toxicity to human cells, while the pre-clinical studies are ongoing. These new antibiotic drug candidates are expected to be developed to complement the current antibiotic drugs for treating bacteria caused infectious diseases, and contributing to the society and healthcare system threatened by antibiotic-resistant bacteria.

AREA/MATURITY/AWARDS

Primary Application Area: Biotech, Pharma

Technology Development Status: Prototype

Technology Readiness Level: TRL 3

SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Showcase Booth #: 319

Website: https://www.polyu.edu.hk

GOVT/EXTERNAL FUNDING SOURCES

External Funding to Date: Hong Kong Research Grant Council Early Career Scheme grant