Keywords: Adverse Outcome Pathways; Nanomaterials; Advanced Materials
Summary:Adverse Outcome Pathways (AOPs) are conceptual frameworks that link key biological events (KEs) resulting from chemical or material exposure to adverse health or environmental impacts (Adverse Outcomes; AOs) important for evaluating safety. To build on the advances in AOP development and investigate the use of AOPs for nanomaterial (NM) safety assessments and decision making, an Organisation for Economic Cooperation and Development (OECD) Working Party on Manufactured Nanomaterials (WPMN) project developed a methodology to use existing nanotoxicology literature to promote NM-relevant AOP development. Two expert workshops were convened to identify technical and translational issues toward development, application and acceptance of the AOP framework and related testing tools for use in NM decision making. This talk will give an overview of the outcomes from this OECD WPMN project which includes (i) a systematic process for mining the nanotoxicity literature to identify potential KEs relevant for NMs; (ii) a strategy to prioritize identified potential KEs for development; and (iii) a methodology for developing prioritized KEs from evidence gathered from the literature to promote NM-relevant AOP development. Expert input from workshops shaped a Community Statement that identifies issues for development, application and acceptance of the AOP framework for use in NM decision making and outlines key recommendations to address them. The demonstrated methodology provides an approach to advance NM-relevant AOP development from existing nanotoxicology literature, without the extensive costs of additional testing. This talk will outline key recommendations from the Community Statement that forms a roadmap of short-, medium- and long-term actions to address key issues in developing and applying the AOP framework for use in NM decision making.