Dr. Clyne is director of the Vascular Kinetics Laboratory, which investigates integrated mechanical and biochemical interactions among cells and proteins of the cardiovascular system. She is particularly interested in how endothelial cell mechanotransduction changes in a diseased environment, and how fluid shear stress and substrate mechanics affect biochemical binding kinetics, transport, and signaling.
Dr. Clyne was inducted into the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows in 2019. She received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. She has received research and educational funding from NSF, NIH, AHA, Department of Education, the Nanotechnology Institute, and the State of Pennsylvania, and she has published in diverse journals including Lab on a Chip, Journal of Biomechanics, Annals of Biomedical Engineering, Tissue Engineering, Biophysical Journal, PLOS One, The Journal of Biological Chemistry, and Circulation. She is a fellow of ASME and the AHA, and a member of ASEE, BMES, NAVBO, and SWE.