Regulation of assembly status and activity of the proteasome as a non-toxic way to mitigate military relevant muscle atrophy

TECHNOLOGY SUMMARY

Loss of skeletal muscle mass and strength is a problem in military-relevant settings including operational stress or post-injury immobilization. In affected muscle cells disassembly of proteins progresses faster than their replenishment. We designed non-toxic small molecules that mitigate the protein loss and restore muscle health in animal model.

AREA/MATURITY/AWARDS

Primary Application Area: Biotech, Pharma, Health

Technology Development Status: Prototype

Technology Readiness Level: TRL 3


SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Website: https://uthscsa.edu


MARKET KEYWORDS

Market Keywords: muscle strength restoration, muscle health, post-injury care