Y. Su, T. Hutter
The University of Texas at Austin,
United States
Keywords: mirco-pore evaporation, glucose preconcentration, water-soluble analytes
Summary:
This study presents the development of a micro-3D printed concentrator designed for efficient solvent evaporation through micro-pores. Operating at temperatures as low as room temperature, the device ensures compatibility with temperature-sensitive biomolecules. It is optimized for processing small sample volumes, ranging from tens to hundreds of microliters. The device consists of a hydrophilic biocompatible polymer tube with uniform micro-pores, enabling controlled evaporation. An outer tube provides sweeping gas flow rates between 20 and 100 mL/min, allowing precise control over the evaporation rate. Performance was characterized using theoretical models and experimental validation, with glucose solutions as a proof of concept to demonstrate its capability in preconcentrating water-soluble chemicals. The device achieved a concentration increase of up to 10-fold. Key factors such as sweeping gas flow rate, liquid sample feed rate, and temperature were analyzed for their impact on device efficiency. This innovative concentrator offers a robust and biocompatible approach to sample concentration, enhancing sensitivity in applications such as bioassays and biosensors. By successfully concentrating glucose, the study highlights the device's potential for broader applications involving water-soluble analytes.