T.J. Webster
Brown University and Hebei University of Technology,
United States
Keywords: infection, bacteria, human studies, animal models, nanomedicine
Summary:
Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For example, this presentation will provide an over 25 year journey of commercializing nano orthopedic implants now in over 30,000 patients to date showing no signs of failure according to the FDA MAUDE database. Current orthopedic implants face a failure rate of 5 – 10% and sometimes as high as 60% for bone cancer patients. As part of this success, new In vitro and in vivo infection models were developed which translated to human studies showing no implant infections among 30,000 patients. Lastly, this talk will summarize recent advances in nanomedicine to both help human health and save the environment.