Z.Q. Cao
Wayne State University,
United States
Keywords: zwitterionic polymer, micelles, drug delivery, peptide delivery
Summary:
Zwitterionic polymers are known for their superhydrophilic properties, which create a strong hydration effect when used as coatings, contributing to their excellent nonfouling characteristics. When nanoparticles are formed with a surface covered by zwitterionic polymers, they exhibit remarkable blood compatibility, resulting in extended blood circulation times. In my presentation, I will introduce polymer surfactants that combine zwitterionic polymers as the superhydrophilic domain with lipids as the superhydrophobic domain. These surfactants, with their sharp polarity contrast, offer unique properties compared to the PEG-lipid gold standard, which is widely used in lipid nanoparticle formulations. I will also discuss several application scenarios of zwitterionic polymer-based surfactants in drug delivery. This research was supported by the National Science Foundation, the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, and Breakthrough T1D.