J.B. Scott, R.J. Solch-Ottaiano, M. Acquarone, D.M. Maraganore
Tulane University,
United States
Keywords: Mediterranean Diet, Western Diet, Gut Microbiota, Memory, Cognitive Function, Probiotic
Summary:
Tulane researchers are developing an innovative oral probiotic derived from gut microbiota associated with a Mediterranean diet. Their research demonstrates that compared to a Western diet, a Mediterranean diet promotes specific bacterial genera linked to improved cognitive performance in young Sprague Dawley rats, enhancing spatial memory, cognitive flexibility, and working memory. The researchers identified changes in gut microbial composition where four bacterial genera increased and five decreased in the Mediterranean diet group compared to the Western diet group. Additionally, the Mediterranean diet influenced peripheral markers, lowering LDL cholesterol levels and modulating cytokine profiles. This oral probiotic aims to support healthy brain aging and address challenges including age-associated cognitive decline, APOE4-linked Alzheimer's risk, and mild cognitive impairment. The formulation shows promise as a cost-effective, safe, and convenient alternative for cognitive preservation and early-stage Alzheimer's management, representing a paradigm shift in preventative therapeutic approaches for brain health.