Biomimetic Microengineering of the Human Intestine and Host-Microbiome Interactions

Hyun Jung Kim

Scientist

Cleveland Clinic

Hyun Jung Kim is an Assistant Staff in the Department of Inflammation and Immunity at Cleveland Clinic and the Principal Investigator of The Biomimetic Microengineering (BioME) Laboratory. His research centers on innovating bioinspired engineering principles to develop advanced biomedical platform technologies that address fundamental questions in human health and disease. Through the development of miniaturized human Organ-on-a-Chip microphysiological systems, the BioME lab has pioneered biomimetic approaches that replicate the structural, functional, and mechanical dynamics of the human intestine (Shin and Kim, PNAS, 2018; Shin and Kim, Nat. Protoc., 2022; Shin & Than et al., Nat. Rev. Bioeng., 2024).

His research group has made significant discoveries about the host-microbiome ecosystem, illuminating its role in human health and disease. By combining clinical microbiology, microfluidics, and tissue engineering, his team has pushed the boundaries of organ-on-a-chip technology and personalized disease modeling. His contributions have been recognized through numerous awards, including the Kenneth Rainin Foundation Innovator Awards (2024, 2016), the VeloSano 10 Pilot Award (2024), the Crohn’s and Colitis Foundation Senior Research Award (2023), the Cleveland Clinic Career Development Program Award (2022), High-Impact High-Risk Research Awards from the Cancer Prevention and Research Institute of Texas (CPRIT) (2021), and the Technology Impact Award from the Cancer Research Institute (2018).