J. Fan, J.H. Lavoie, L. Masciolini, B. Pourdeyhimi, C. Boi, R.G. Carbonell
North Carolina State University,
United States
Keywords: membranes, bioprocesses, downstream
Summary:
There is an increasing demand for more efficient, flexible, and sustainable bioprocessing for a diverse and rapidly growing number of biotherapeutic modalities. This is driving the development of innovative approaches to downstream processing, which remains one of the main bottlenecks in biomanufacturing. This presentation describes advances in novel nonwoven based membrane chromatography materials and devices that can be used in both bind-and-elute and flow-through modes for the capture, purification and polishing of a wide range of biopharmaceuticals. These all-membrane processes exhibit much higher productivities, shorter overall processing times, smaller operating and capital costs, and fewer eCO2 emissions than traditional processes using column resin chromatography. This talk describes the properties of these membranes, their use in the purification of antibodies and other therapeutics from both mammalian and microbial sources, and compares their performance to traditional resin column processes.