N.A. Nunn, A.N. Marek, O.A. Shenderova
Adamas Nanotechnologies, Inc.,
United States
Keywords: quantum sensing; reactive oxygen species; oxidative stress; biomanufacturing; bioreactors; diagnostics; lateral flow assay
Summary:
Adamas Nanotechnologies specializes in the development of nanodiamond-based quantum sensors. These sensors work through nitrogen-vacancy color centers in diamond nanoparticles (NDNV), which are spin-containing, light-addressable sensors with an optical readout highly sensitive to external fields and their local environment. While quantum sensing allows for improved sensitivity, resolution, and speed compared to classical sensors, the translational potential of these sensors lies in equipping researchers with accessible measurement tools that offer expanded capabilities. Nanodiamonds specifically allow for cellular-level sensing. Here we report our advances in the development of quantum-ready nanodiamond and accompanying specialized instrumentation to enable adoption by biomedical research and clinical sectors. The use of these NDNV sensors has been demonstrated in the sensing of paramagnetic metabolites, paving the way for detection of reactive oxygen species in biological systems ranging from blood analysis to biomanufacturing. Another clinically relevant example includes diagnostics, where the sensitivity of lateral flow assays is significantly improved by using NDNV reporters to allow for earlier detection.