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Kilogram scale production of active and stable membrane proteins in vesicles
The core capabilities of Aquaporin A/S are 1) Fermentation and purification of membrane proteins at kilogram scale 2) Design of polymersomes leading to highly stable and active membrane protein formulation 3) Development and production of water filtration membranes based on this biomimetic technique Traditionally, membrane proteins are produced in research labs or assayed directly in living cells. Aquaporin's production process constitutes the largest scale membrane proteins have ever been produced at. Further, we have proven capabilities to formulate active and stable membrane proteins in large scale and at a cost orders of magnitude lower than conventional methods. This allows a new paradigme in applications of membrane proteins, simply due to availability and cost.
Accelerated wound healing using natural materials delivered subdermally in a nanoparticle dispersion
Research has established that birch bark triterpenes (TE) have notable wound healing properties. On a cellular level, TE enhances re-epithelialization and reformation of the epithelial barrier. Other research has shown improved epidermal tissue reconstitution, significantly enhancing cell proliferation in the basal layer and promoting the development of a well-formed stratum corneum. A recent research partnership has allowed us to create a novel, nano technology delivery system to deliver these triterpenes subdermally to improve efficacy. This technology was successfully demonstrated by Dr Eric Morrison in a Phase 1 NSF grant which showed the ability of this system to deliver ibuprofen subdermally through topical application. This delivery system can also be applied to other natural products and anti oxidant vitamins for wound and skin care applications
A nontoxic and novel way to prevent and treat cancer and inflammatory disease
We examined the expression of every single gene to find the most promising targets we can use to prevent and treat cancer. Our immediate efforts utilize our lead compound (called “MASL”) to target a unique receptor (called “PDPN”) on cancer cells. PDPN promotes cancer motility, invasion, and metastasis. We can use MASL to prevent and treat many forms of cancer. In addition, PDPN promotes inflammatory destruction leading to rheumatoid and osteoarthritis. MASL can be used to prevent and treat disease in addition to cancer.
